I never noticed how much difference color modes had over RAM usage until recently! (This program in the gif is Krita).
CMYK uses 41.5 MiB per layer, RGB uses 33.2 MiB, and Grayscale uses 16.6 MiB! It probably doesn't sound like too much~ that is, until you accrue X amount of layers while multitasking other programs. Save often and back up your important files, everyone!
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